Printing and prototyping of tissues and scaffolds

Science. 2012 Nov 16;338(6109):921-6. doi: 10.1126/science.1226340.


New manufacturing technologies under the banner of rapid prototyping enable the fabrication of structures close in architecture to biological tissue. In their simplest form, these technologies allow the manufacture of scaffolds upon which cells can grow for later implantation into the body. A more exciting prospect is the printing and patterning in three dimensions of all the components that make up a tissue (cells and matrix materials) to generate structures analogous to tissues; this has been termed bioprinting. Such techniques have opened new areas of research in tissue engineering and regenerative medicine.

Publication types

  • Review

MeSH terms

  • Bioprinting / methods*
  • Cartilage / cytology
  • Cartilage / physiology
  • Cartilage / radiation effects
  • Humans
  • Photochemical Processes
  • Prostheses and Implants*
  • Regenerative Medicine
  • Tissue Engineering / methods*
  • Tissue Scaffolds*