An analysis of the relationship between ankle-brachial index and estimated glomerular filtration rate in type 2 diabetes

Angiology. 2013 Apr;64(3):237-41. doi: 10.1177/0003319712464515. Epub 2012 Nov 15.


We investigated the relationship between peripheral arterial disease (PAD) and renal function in patients with type 2 diabetes mellitus (T2DM). We enrolled 2057 hospitalized patients with T2DM and measured kidney function and ankle-brachial index (ABI). The estimated glomerular filtration rate (eGFR) was derived using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and ABI was grouped as low (<0.9), low-normal (0.9-1.09), normal (1.1-1.3), and high (>1.3). Logistic regression was used to evaluate the associations of eGFR with ABI. Generally speaking, the ABI was negatively correlated with systolic blood pressure, fasting C-peptide, total cholesterol, and low-density lipoprotein cholesterol while positively correlated with body mass index (P < .05 to <.01). Only a low ABI was positively correlated with eGFR (P < .01). In addition to the association of the ABI with cardiovascular events, stroke, and PAD, ABI may also predict the change in renal function in patients with T2DM.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Ankle Brachial Index*
  • Body Mass Index
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Diabetic Angiopathies / physiopathology*
  • Female
  • Glomerular Filtration Rate / physiology*
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Peripheral Arterial Disease / physiopathology*
  • Renal Insufficiency, Chronic