Immunization of macaques with soluble HIV type 1 and influenza virus envelope glycoproteins results in a similarly rapid contraction of peripheral B-cell responses after boosting

J Infect Dis. 2013 Feb 1;207(3):426-31. doi: 10.1093/infdis/jis696. Epub 2012 Nov 16.


The envelope glycoproteins (Env) represent a critical component of a successful antibody-mediated human immunodeficiency virus type 1 (HIV-1) vaccine. However, immunization with soluble Env was reported to induce short-lived antibody responses, suggesting that Env has unusual immunogenic properties. Here, we directly compared the magnitude and durability of B-cell responses induced by HIV-1 Env and an unrelated soluble viral protein, influenza virus hemagglutinin (HA), in simultaneously inoculated macaques. We demonstrate robust peak responses followed by rapid contraction of circulating antibody and memory B cells for both antigens, suggesting that short-lived responses are not unique to HIV-1 Env but may be a common feature of soluble protein vaccines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS Vaccines / immunology
  • Animals
  • Antibodies, Viral / blood
  • Antibodies, Viral / immunology
  • Antibody Specificity / immunology
  • B-Lymphocytes / immunology*
  • Female
  • HIV Antibodies / blood
  • HIV Antibodies / immunology
  • HIV-1 / immunology*
  • Immunity, Humoral
  • Immunization*
  • Immunization, Secondary
  • Influenza Vaccines / immunology
  • Macaca / immunology
  • Orthomyxoviridae / immunology*
  • Recombinant Proteins / immunology
  • Viral Envelope Proteins / immunology*


  • AIDS Vaccines
  • Antibodies, Viral
  • HIV Antibodies
  • Influenza Vaccines
  • Recombinant Proteins
  • Viral Envelope Proteins