Comparative evaluation of 0.1% turmeric mouthwash with 0.2% chlorhexidine gluconate in prevention of plaque and gingivitis: A clinical and microbiological study

J Indian Soc Periodontol. 2012 Jul;16(3):386-91. doi: 10.4103/0972-124X.100917.


Background: The aim of our clinical trial was to assess the efficacy of 0.1% turmeric mouthwash as an anti-plaque agent and its effect on gingival inflammation and to compare it with 0.2% chlorhexidine gluconate by evaluating the effect on plaque and gingival inflammation and on microbial load.

Materials and methods: 60 subjects, 15 years and above, with mild to moderate gingivitis were recruited. Study population was divided into two groups. Group A-30 subjects were advised chlorhexidine gluconate mouthwash. Group B-30 subjects were advised experimental (turmeric) mouthwash. Both the groups were advised to use 10 ml of mouthwash with equal dilution of water for 1 min twice a day 30 min after brushing. Parameters were recorded for plaque and gingival index at day 0, on 14 (th) day, and 21 (st) day. Subjective and objective criteria were assessed after 14(th) day and 21(st) day. The N-benzoyl-l-arginine-p- nitroanilide (BAPNA) assay was used to analyze trypsin like activity of red complex microorganisms.

Results: On comparison between chlorhexidine and turmeric mouthwash, percentage reduction of the Plaque Index between 0 and 21 (st) day were 64.207 and 69.072, respectively (P=0.112), percentage reduction of Gingival Index between 0 and 21(st) day were 61.150 and 62.545 respectively (P=0.595) and percentage reduction of BAPNA values between 0 and 21(st) day were 42.256 and 48.901 respectively (P=0.142).

Conclusion: Chlorhexidine gluconate as well as turmeric mouthwash can be effectively used as an adjunct to mechanical plaque control in prevention of plaque and gingivitis. Both the mouthwashes have comparable anti-plaque, anti-inflammatory and anti-microbial properties.

Keywords: BAPNA; Chlorhexidine gluconate mouthwash; turmeric mouthwash.