A new vaccine against tick-borne encephalitis: initial trial in man including a dose-response study

Vaccine. 1990 Feb;8(1):22-4. doi: 10.1016/0264-410x(90)90172-i.

Abstract

A new vaccine against tick-borne encephalitis was investigated in 56 healthy volunteers randomized for five different doses of antigen in a comparative group trial. Good tolerability and high immunogenicity were found using three different antibody test systems. The dose response study revealed that there was a strong relationship between the amount of antigen administered and the antibody response over the range of 0.03-3.0 micrograms antigen per dose.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Animals
  • Antibodies, Viral / biosynthesis*
  • Chick Embryo
  • Dose-Response Relationship, Immunologic
  • Encephalitis Viruses, Tick-Borne / immunology*
  • Encephalitis, Tick-Borne / prevention & control*
  • Enzyme-Linked Immunosorbent Assay
  • Hemagglutination Inhibition Tests
  • Humans
  • Male
  • Middle Aged
  • Neutralization Tests
  • Random Allocation
  • Vaccines, Inactivated / adverse effects
  • Vaccines, Inactivated / immunology
  • Viral Vaccines / adverse effects
  • Viral Vaccines / immunology*

Substances

  • Antibodies, Viral
  • Vaccines, Inactivated
  • Viral Vaccines