Abstract
A new vaccine against tick-borne encephalitis was investigated in 56 healthy volunteers randomized for five different doses of antigen in a comparative group trial. Good tolerability and high immunogenicity were found using three different antibody test systems. The dose response study revealed that there was a strong relationship between the amount of antigen administered and the antibody response over the range of 0.03-3.0 micrograms antigen per dose.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adult
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Animals
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Antibodies, Viral / biosynthesis*
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Chick Embryo
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Dose-Response Relationship, Immunologic
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Encephalitis Viruses, Tick-Borne / immunology*
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Encephalitis, Tick-Borne / prevention & control*
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Enzyme-Linked Immunosorbent Assay
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Hemagglutination Inhibition Tests
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Humans
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Male
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Middle Aged
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Neutralization Tests
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Random Allocation
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Vaccines, Inactivated / adverse effects
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Vaccines, Inactivated / immunology
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Viral Vaccines / adverse effects
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Viral Vaccines / immunology*
Substances
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Antibodies, Viral
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Vaccines, Inactivated
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Viral Vaccines