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Editorial
. 2012 Dec 15;11(24):4487-8.
doi: 10.4161/cc.22666. Epub 2012 Nov 19.

Uncovering the Interplay Between DNA Sequence Preferences of Transcription Factors and Nucleosomes

Free PMC article
Editorial

Uncovering the Interplay Between DNA Sequence Preferences of Transcription Factors and Nucleosomes

Sarah A Teichmann et al. Cell Cycle. .
Free PMC article

Figures

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Figure 1. Summary of in vitro and in vivo TF and nucleosome-binding landscapes. Based on TF and nucleosome intrinsic (in vitro) preferences, only the binding sites of HA and only very strong HC should be accessible. In the YPD growth medium (in vivo), however, nucleosomes can be disrupted/repositioned from their “preferred” DNA sequences upon the binding of HC TFs. Lower nucleosome occupancy is observed over clusters of multiple TF-binding sites, especially the sites bound by HC TFs and those that match strongly with consensus motifs. This results in more binding sites becoming accessible and a concomitant increase in gene expression.

Comment on

  • Charoensawan V, Janga SC, Bulyk ML, Babu MM, Teichmann SA. DNA sequence preferences of transcriptional activators correlate more strongly than repressors with nucleosomes. Mol Cell. 2012;47:183–92. doi: 10.1016/j.molcel.2012.06.028.

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References

    1. Shivaswamy S, et al. PLoS Biol. 2008;6:e65. doi: 10.1371/journal.pbio.0060065. - DOI - PMC - PubMed
    1. Kumar SV, et al. Nature. 2012;484:242–5. doi: 10.1038/nature10928. - DOI - PMC - PubMed
    1. Zaugg JB, et al. Genome Res. 2012;22:84–94. doi: 10.1101/gr.124099.111. - DOI - PMC - PubMed
    1. Bai L, et al. Mol Cell. 2011;42:465–76. doi: 10.1016/j.molcel.2011.03.028. - DOI - PMC - PubMed
    1. Ganapathi M, et al. Nucleic Acids Res. 2011;39:2032–44. doi: 10.1093/nar/gkq1161. - DOI - PMC - PubMed

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