Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

Chem Commun (Camb). 2013 Mar 21;49(23):2287-9. doi: 10.1039/c2cc36844g.

Abstract

The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Detergents / chemistry
  • Glucose / chemistry*
  • Glycols / chemistry*
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism
  • Protein Stability
  • Rhodobacter capsulatus / metabolism

Substances

  • Detergents
  • Glycols
  • Membrane Proteins
  • Glucose