Nutritional supplementation assessment with whey proteins and TGF-β in patients with Crohn's disease

Nutr Hosp. Jul-Aug 2012;27(4):1286-92. doi: 10.3305/nh.2012.27.4.5795.

Abstract

Crohn's disease (CD) is a chronic inflammatory disorder that primarily affects the intestines, resulting in breakage of the intestinal barrier, pathological inflammation and nutritional disorders that encompass from trace elements deficiency to severe malnutrition. Nutritional interventions either alone or associated to drug therapy may be effective to achieve and maintain inflammation remission.

Objective: To evaluate usual food intake as quantitative and qualitatively, in CD patients; and describe the effect of a supplement containing whey proteins and TGF- on their body composition.

Patients and methods: Dietary intake was assessed considering 42 consecutive patients, followed in a tertiary center, and by using the 3-day food recall and food intake frequency questionnaire. Body composition was assessed previously and 8 weeks after supplementation with a diet containing whey proteins and TGF-β (N = 22).

Results and discussion: Considering carbohydrates and lipids, most patients had adequate dietary intake according recommendations. Protein, saturated fat, B12 vitamin and zinc intakes were higher than the recommended values. The dietary fiber, A, D, C and E vitamins, calcium, iron, folate, potassium and sodium intakes did not reach the recommended requirements in most patients. Patients supplemented with the whey protein and TGF-β dietary presented a positive increment in their lean body mass, when compared to non-supplemented group.

Conclusion: CD patients require nutritional orientation. Whey protein intake resulted in significant differences, such as improvement in Lean Body Mass and reduction in Fat percentage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / physiology
  • Adolescent
  • Adult
  • Body Composition / physiology
  • Crohn Disease / diet therapy*
  • Diet
  • Dietary Supplements*
  • Eating
  • Female
  • Humans
  • Male
  • Middle Aged
  • Milk Proteins / therapeutic use*
  • Nutrition Assessment
  • Nutrition Policy
  • Transforming Growth Factor beta / therapeutic use*
  • Whey Proteins
  • Young Adult

Substances

  • Milk Proteins
  • Transforming Growth Factor beta
  • Whey Proteins