Dendritic cell subsets in mycobacterial infection: control of bacterial growth and T cell responses

Tuberculosis (Edinb). 2013 Mar;93(2):115-22. doi: 10.1016/ Epub 2012 Nov 16.


Anti-mycobacterial immunity is guided by specialised antigen presenting cells known as dendritic cells, which are essential for both initiating and maintaining T cell immune responses during infection. The dendritic cell population can be divided into functionally distinct subsets that differ in their ability to present antigen and produce key TH1 cytokines, such as IL-12. This review discusses recent studies, in murine models, investigating which dendritic cell populations are important for mycobacterial control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Dendritic Cells / immunology*
  • Disease Models, Animal
  • Interleukin-12 / biosynthesis
  • Mice
  • Mycobacterium / growth & development*
  • Mycobacterium Infections / immunology*
  • Mycobacterium Infections / microbiology
  • T-Lymphocytes / immunology*


  • Interleukin-12