Targeting the right regulatory T-cell population for tumor immunotherapy

Oncoimmunology. 2012 Oct 1;1(7):1191-1193. doi: 10.4161/onci.20664.


Regulatory T cells (Tregs) that suppress tumor-specific T cell-mediated immune responses are the subject of an intense wave of investigation. We recently reported that a subset of Tregs, namely effector/memory CD25(low) cells, are responsible for suppressing high avidity tumor-specific T cells in mouse mammary tumors. Here, we discuss additional findings that clarify this mechanism of Treg-mediated immunosuppression.