A nomogram for perioperative prognostic risk-assessment in twin-twin transfusion syndrome

Prenat Diagn. 2013 Feb;33(2):103-8. doi: 10.1002/pd.4015. Epub 2012 Nov 21.


Objective: Prognostic assessment in twin-to-twin transfusion syndrome (TTTS) is ill-defined. The objective of this study is to define a perioperative prognostic score for TTTS treated by percutaneous laser coagulation.

Methods: Consecutive cases of TTTS treated by percutaneous fetoscopic laser coagulation over a 6-year period were reviewed. Twin survival at 28 days was considered using a 3-level polytomous variable defined by 0, 1, or 2 fatal events. A multivariate prognostic analysis with internal validation was conducted using gestational age at diagnosis, weight discordance, umbilical artery, and ductus venosus abnormalities in the donor and the recipient respectively, cervical length, selectivity of surgery, and transplacental approach.

Results: On the basis of 507 cases, the perinatal survival rate of 2 and 1 twin was 46.2% and 31.5%, respectively. Statistically significant factors included umbilical artery abnormalities in the donor, gestational age, and transplacental approach, but with different effects regarding survival of 0, 1, or 2 twins. A scoring chart was subsequently constructed together with a nomogram for both a preoperative and immediate post-operative prognostic assessment.

Conclusion: Part of the prognosis can be anticipated by perioperative findings. Although further validation is required, the presented nomogram should help unify the prognostic assessment in TTTS.

MeSH terms

  • Female
  • Fetofetal Transfusion / diagnosis*
  • Fetofetal Transfusion / mortality
  • Fetofetal Transfusion / surgery
  • Humans
  • Laser Coagulation*
  • Logistic Models
  • Nomograms
  • Perioperative Period
  • Pregnancy
  • Pregnancy, Twin*
  • Prognosis
  • Risk Assessment
  • Twins