Abstract
The expression of MHC class I molecules is crucial for the initiation and regulation of adaptive immune responses against pathogens. NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes (CITA). NLRC5 and the master regulator for MHC class II genes, class II transactivator (CIITA), interact with similar MHC promoter-bound factors. Here, we provide a broad overview of the molecular mechanisms behind MHC class I transcription and the role of the class I transactivator NLRC5 in MHC class I-dependent immune responses.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptive Immunity / genetics
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Adaptive Immunity / immunology*
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Animals
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Gene Expression Regulation / genetics
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Gene Expression Regulation / immunology
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Genes, MHC Class I / genetics
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Genes, MHC Class I / immunology*
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Humans
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Intracellular Signaling Peptides and Proteins / genetics
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Intracellular Signaling Peptides and Proteins / immunology*
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Intracellular Signaling Peptides and Proteins / metabolism
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Mice
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Nuclear Proteins / genetics
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Nuclear Proteins / immunology
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Nuclear Proteins / metabolism
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Promoter Regions, Genetic / immunology
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Trans-Activators / genetics
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Trans-Activators / immunology
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Trans-Activators / metabolism
Substances
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Intracellular Signaling Peptides and Proteins
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MHC class II transactivator protein
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NLRC5 protein, human
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NLRC5 protein, mouse
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Nuclear Proteins
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Trans-Activators