NLRC5: a key regulator of MHC class I-dependent immune responses

Nat Rev Immunol. 2012 Dec;12(12):813-20. doi: 10.1038/nri3339.


The expression of MHC class I molecules is crucial for the initiation and regulation of adaptive immune responses against pathogens. NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes (CITA). NLRC5 and the master regulator for MHC class II genes, class II transactivator (CIITA), interact with similar MHC promoter-bound factors. Here, we provide a broad overview of the molecular mechanisms behind MHC class I transcription and the role of the class I transactivator NLRC5 in MHC class I-dependent immune responses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity / genetics
  • Adaptive Immunity / immunology*
  • Animals
  • Gene Expression Regulation / genetics
  • Gene Expression Regulation / immunology
  • Genes, MHC Class I / genetics
  • Genes, MHC Class I / immunology*
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / immunology*
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Mice
  • Nuclear Proteins / genetics
  • Nuclear Proteins / immunology
  • Nuclear Proteins / metabolism
  • Promoter Regions, Genetic / immunology
  • Trans-Activators / genetics
  • Trans-Activators / immunology
  • Trans-Activators / metabolism


  • Intracellular Signaling Peptides and Proteins
  • MHC class II transactivator protein
  • NLRC5 protein, human
  • NLRC5 protein, mouse
  • Nuclear Proteins
  • Trans-Activators