Monosomy 3 and isochromosome 8q in a uveal melanoma

Cancer Genet Cytogenet. 1990 Apr;45(2):249-53. doi: 10.1016/0165-4608(90)90090-w.


Chromosome analysis of a locally invasive uveal melanoma revealed monosomy 3 and i(8q). Sublines with multiple copies of the i(8q) were also present. Loss of heterozygosity for genes on chromosome 3 and duplication of genes on 8q may play an important role in progression of uveal melanoma.

Publication types

  • Case Reports

MeSH terms

  • Chromosome Aberrations*
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 3*
  • Chromosomes, Human, Pair 8*
  • Humans
  • Karyotyping
  • Male
  • Melanoma / genetics*
  • Middle Aged
  • Monosomy*
  • Multigene Family
  • Uveal Neoplasms / genetics*