Changes in the adult vertebrate auditory sensory epithelium after trauma

Hear Res. 2013 Mar;297:91-8. doi: 10.1016/j.heares.2012.11.010. Epub 2012 Nov 20.


Auditory hair cells transduce sound vibrations into membrane potential changes, ultimately leading to changes in neuronal firing and sound perception. This review provides an overview of the characteristics and repair capabilities of traumatized auditory sensory epithelium in the adult vertebrate ear. Injured mammalian auditory epithelium repairs itself by forming permanent scars but is unable to regenerate replacement hair cells. In contrast, injured non-mammalian vertebrate ear generates replacement hair cells to restore hearing functions. Non-sensory support cells within the auditory epithelium play key roles in the repair processes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Brain-Derived Neurotrophic Factor / metabolism
  • Ear, Inner / physiology*
  • Ear, Inner / physiopathology
  • Epithelium / pathology*
  • Hair Cells, Auditory / physiology*
  • Hearing
  • Hearing Loss, Noise-Induced / physiopathology
  • Humans
  • Membrane Potentials
  • Nerve Regeneration / physiology*
  • Organ of Corti / physiopathology
  • Regeneration / physiology*
  • Spiral Ganglion / pathology
  • Stem Cell Transplantation / methods
  • Vertebrates / physiology
  • Wounds and Injuries*


  • Brain-Derived Neurotrophic Factor