The product of fem-1, a nematode sex-determining gene, contains a motif found in cell cycle control proteins and receptors for cell-cell interactions

Cell. 1990 Mar 23;60(6):981-90. doi: 10.1016/0092-8674(90)90346-g.


We report the cloning and sequencing of fem-1, a gene required for sex determination in both germline and somatic tissues in the nematode C. elegans. Clones carrying a 5.5 kb fragment are able to rescue the progeny of a fem-1 mutant when injected into its oocytes. The major fem-1 transcript in both sexes is 2.4 kb and comprises 11 exons. It encodes a soluble, intracellular protein of 656 amino acids that includes near its N-terminus six contiguous copies of a motif found in the products of the cdc10 gene of S. pombe, the SWI6 gene of S. cerevisiae, the Notch gene of Drosophila, and the lin-12 and glp-1 genes of C. elegans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Caenorhabditis / genetics*
  • Caenorhabditis / physiology
  • Cell Communication*
  • Cell Cycle / genetics*
  • Cell Cycle Proteins / chemistry
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / physiology
  • Chromosome Mapping
  • Cloning, Molecular
  • Female
  • Gene Rearrangement
  • Intercellular Junctions / physiology*
  • Introns
  • Male
  • Molecular Sequence Data
  • Mutation
  • Polymorphism, Genetic
  • Repetitive Sequences, Nucleic Acid
  • Sequence Homology, Nucleic Acid
  • Sex Differentiation / genetics*
  • Transformation, Genetic


  • Cell Cycle Proteins

Associated data

  • GENBANK/J03172