Tet-Transgenic Rodents: A Comprehensive, Up-To Date Database

Transgenic Res. 2013 Apr;22(2):251-4. doi: 10.1007/s11248-012-9660-9. Epub 2012 Nov 23.

Abstract

Here we introduce the "Tet-Transgenic Rodents" database, documenting most of the published Tet-transgenic mouse lines generated in the past 2 decades. Aside from the >500 mouse lines listed, it also includes the first of the recently reported Tet-transgenic rat models. Since the Tet technology comprises two essential components, a cis-acting promoter (Ptet) and a trans-acting transactivator, the database has been organized accordingly. One section of the database summarizes the different transgenic mouse lines carrying mostly tissue specific promoters driving the Tet transactivator. Another section covers transgenic mouse lines carrying responder transgenes under Ptet control. The few existing rat transgenic lines are listed correspondingly. It is the purpose of this database to facilitate the repeated use of preexisting, validated transgenic lines as a shortcut for further research.

MeSH terms

  • Animals
  • Animals, Genetically Modified / classification*
  • Animals, Genetically Modified / genetics
  • Databases, Genetic*
  • Mice
  • Promoter Regions, Genetic
  • Rats
  • Repressor Proteins / genetics*

Substances

  • Repressor Proteins
  • tetracycline resistance-encoding transposon repressor protein