Differential Serotonergic Modulation of Two Types of Aggression in Weakly Electric Fish

Front Behav Neurosci. 2012 Nov 19;6:77. doi: 10.3389/fnbeh.2012.00077. eCollection 2012.

Abstract

Agonistic aggression has provided an excellent framework to study how conserved circuits and neurochemical mediators control species-specific and context-dependent behavior. The principal inhibitory control upon aggression is serotonin (5-HT) dependent, and the activation of 5-HT(1A) receptors is involved in its action. To address whether the serotonergic system differentially regulates different types of aggression, we used two species of weakly electric fish: the solitary Gymnotus omarorum and the gregarious Brachyhypopomus gauderio, which display distinctive types of aggression as part of each species' natural behavioral repertoire. We found that in the reproduction-related aggression displayed by B. gauderio after conflict resolution, the serotonergic activity follows the classic pattern in which subordinates exhibit higher 5-HT levels than controls. After the territorial aggression displayed by G. omarorum, however, both dominants and subordinates show lower 5-HT levels than controls, indicating a different response of the serotonergic system. Further, we found interspecific differences in basal serotonin turnover and in the dynamic profile of the changes in 5-HT levels from pre-contest to post-contest. Finally, we found the expected reduction of aggression and outcome shift in the territorial aggression of G. omarorum after 8-OH-DPAT (5-HT(1A) receptor agonist) administration, but no effect in the reproduction-related aggression of B. gauderio. Our results demonstrate the differential participation of the serotonergic system in the modulation of two types of aggression that we speculate may be a general strategy of the neuroendocrine control of aggression across vertebrates.

Keywords: 5-HT; Brachyhypopomus gauderio; Gymnotus omarorum; agonistic behavior; reproduction-related aggression; territorial aggression.