Reduced alpha and exaggerated theta power during the resting-state EEG in fragile X syndrome

Biol Psychol. 2013 Feb;92(2):216-9. doi: 10.1016/j.biopsycho.2012.11.013. Epub 2012 Nov 24.


This study characterizes the resting-state EEG in males with fragile X syndrome to reveal abnormalities in oscillatory brain dynamics. Analyses of the eyes-closed EEG epochs showed that the resting-state EEG in FXS can be characterized by elevated relative theta power (4-8 Hz) and reduced relative upper-alpha power (10-12 Hz). Although preliminary, these findings suggest that the well-documented imbalance in excitatory/inhibitory cortical circuit activity in FXS can be revealed the level of oscillatory behavior at the scalp. A next step for future studies is linking the EEG resting-state indices to cognitive and behavioral measures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alpha Rhythm / physiology*
  • Analysis of Variance
  • Brain Mapping
  • Case-Control Studies
  • Electroencephalography
  • Fragile X Syndrome / physiopathology*
  • Humans
  • Male
  • Rest*
  • Spectrum Analysis
  • Theta Rhythm / physiology*
  • Young Adult