Abstract
A series of Ru(II) catalysts inspired by the metalloenzyme nitrile hydratase catalyze the hydration of benzonitrile with up to 242 turnovers under neutral conditions with very low catalysts loading. Catalysts with an oxidized sulfur environment are less susceptible to product inhibition increasing the catalytic efficiency at low nitrile : water ratios.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Biocompatible Materials / chemistry*
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Biocompatible Materials / metabolism
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Catalysis
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry*
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Hydro-Lyases / chemistry
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Hydro-Lyases / metabolism
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Hydrogen-Ion Concentration
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Nitriles / chemistry*
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Oxidation-Reduction
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Ruthenium / chemistry*
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Sulfhydryl Compounds / chemistry*
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Sulfur / chemistry
Substances
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Biocompatible Materials
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Coordination Complexes
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Nitriles
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Sulfhydryl Compounds
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Sulfur
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Ruthenium
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benzonitrile
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Hydro-Lyases
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nitrile hydratase