The impact of deep brain stimulation on the nonmotor symptoms of Parkinson's disease

J Neural Transm (Vienna). 2013 Apr;120(4):639-42. doi: 10.1007/s00702-012-0912-x. Epub 2012 Nov 27.


Deep brain stimulation (DBS) is a well-established therapy for patients with advanced Parkinson's disease (PD) with clear benefits on many of the motor symptoms. The effects of DBS on the nonmotor symptoms are less well examined. Emergence of tools to measure the nonmotor burden in PD is now allowing a more objective assessment of impact of DBS on such symptoms. Here we review the pertinent evidence and conclude that, as a therapy, DBS has a major potential to contribute towards the holistic care of PD patients.

Publication types

  • Review

MeSH terms

  • Deep Brain Stimulation*
  • Humans
  • Pain / complications
  • Pain Management
  • Parkinson Disease / complications
  • Parkinson Disease / therapy*
  • Treatment Outcome
  • Urinary Bladder, Overactive / complications
  • Urinary Bladder, Overactive / therapy*