Mimicking the biological ligand-receptor principle for universal target gene delivery mediated by avidin-biotin interaction

Adv Healthc Mater. 2013 Mar;2(3):418-21. doi: 10.1002/adhm.201200206. Epub 2012 Oct 8.

Abstract

A facile and flexible targeting gene-delivery strategy is reported by mimicking the biological ligand-receptor principle based on avidin-biotin interaction. In vitro and in vivo investigations demonstrate that this strategy provides a simple, but universal alternative for potential target gene delivery as well as drug delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inducing Agents / metabolism
  • Angiogenesis Inducing Agents / pharmacology
  • Animals
  • Avidin / chemistry*
  • Avidin / metabolism*
  • Biotin / chemistry*
  • Biotin / metabolism*
  • COS Cells
  • Cell Membrane / chemistry
  • Cell Membrane / metabolism
  • Cell Survival
  • Chlorocebus aethiops
  • DNA / chemistry
  • DNA / genetics
  • DNA / metabolism
  • Endocytosis
  • Gene Transfer Techniques*
  • HeLa Cells
  • Hindlimb / physiopathology
  • Humans
  • Ischemia / therapy
  • Muscle, Skeletal / chemistry
  • Muscle, Skeletal / metabolism
  • Rats
  • Vascular Endothelial Growth Factor A / genetics
  • Vascular Endothelial Growth Factor A / metabolism
  • Vascular Endothelial Growth Factor A / pharmacology

Substances

  • Angiogenesis Inducing Agents
  • Vascular Endothelial Growth Factor A
  • Avidin
  • Biotin
  • DNA