DoBISCUIT: A Database of Secondary Metabolite Biosynthetic Gene Clusters

Nucleic Acids Res. 2013 Jan;41(Database issue):D408-14. doi: 10.1093/nar/gks1177. Epub 2012 Nov 26.

Abstract

This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or candidates for drug development. Biosynthesis of each secondary metabolite is catalyzed by a number of enzymes, usually encoded by a gene cluster. Although many scientific papers describe such gene clusters, the gene information is not always described in a comprehensive manner and the related information is rarely integrated. DoBISCUIT integrates the latest literature information and provides standardized gene/module/domain descriptions related to the gene clusters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteria / genetics
  • Bacteria / metabolism*
  • Databases, Genetic*
  • Genes, Bacterial*
  • Internet
  • Multigene Family
  • Peptide Synthases / genetics
  • Polyketide Synthases / genetics
  • User-Computer Interface

Substances

  • Polyketide Synthases
  • Peptide Synthases
  • non-ribosomal peptide synthase