The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials

PLoS Med. 2012;9(11):e1001346. doi: 10.1371/journal.pmed.1001346. Epub 2012 Nov 20.


The Ottawa Ethics of Cluster Trials Consensus Group sets out 15 recommendations for the ethical design and conduct of cluster randomized trials.

Publication types

  • Guideline
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cluster Analysis*
  • Epidemiologic Research Design*
  • Humans
  • Randomized Controlled Trials as Topic / ethics*
  • Randomized Controlled Trials as Topic / methods*