The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation

J Clin Invest. 2012 Dec;122(12):4325-8. doi: 10.1172/JCI66420. Epub 2012 Nov 26.


The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint. Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis, implicating USP44 as novel tumor suppressor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Aneuploidy*
  • Animals
  • Cell Transformation, Neoplastic / genetics*
  • Centrosome / metabolism*
  • Endopeptidases / physiology*
  • Genes, Tumor Suppressor*
  • Humans
  • Tumor Suppressor Proteins / physiology*
  • Ubiquitin Thiolesterase


  • Tumor Suppressor Proteins
  • Endopeptidases
  • USP44 protein, mouse
  • Ubiquitin Thiolesterase