Survey of depression by Beck Depression Inventory in uremic patients undergoing hemodialysis and hemodiafiltration

Ther Apher Dial. 2012 Dec;16(6):573-9. doi: 10.1111/j.1744-9987.2012.01094.x. Epub 2012 Aug 7.


High prevalence of depression has been reported in patients with end stage kidney disease and depression is associated with increased morbidity and mortality. We aimed to investigate the prevalence of depression in patients receiving standard hemodialysis (SHD) and hemodiafiltration (HDF) and compare the associated factors between these treatment modalities. The Beck Depression Inventory (BDI) was used to survey for major depressive symptoms. Demographic and biochemical data were reviewed and collected. Point prevalence of depression in HDF patients was significantly lower than SHD patients (23.9% vs. 43.1%, P < 0.05). The BDI score was also higher in SHD than HDF group (13.2 ± 11.6 vs. 8.7 ± 11.2, P < 0.05). SHD patients with major depressive symptoms had significantly lower levels of hemoglobin, albumin, creatinine, sodium and hand grip strength but had higher prevalence of diabetes and high sensitivity C-reactive protein (hs-CRP) levels. In HDF patients, phosphorus level was significantly lower in patients with major depressive symptoms. Logistic regression analysis revealed that hs-CRP, serum sodium and hand grip strength were significantly associated with major depressive symptoms in patients treated with SHD; while serum phosphorus was identified in HDF groups. We concluded that prevalence of depression was high in dialysis patients. Patients receiving HDF had a lower mean BDI score and a nearly 50% lower prevalence rate of major depressive symptoms than that of SHD. Factors associated with depression were different between two modalities.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • C-Reactive Protein / metabolism
  • Depressive Disorder, Major / epidemiology*
  • Depressive Disorder, Major / physiopathology
  • Female
  • Hand Strength
  • Hemodiafiltration*
  • Hemoglobins / metabolism
  • Humans
  • Kidney Failure, Chronic / therapy*
  • Logistic Models
  • Male
  • Middle Aged
  • Phosphorus / blood
  • Prevalence
  • Psychiatric Status Rating Scales
  • Renal Dialysis*
  • Sodium / blood
  • Uremia / epidemiology


  • Hemoglobins
  • Phosphorus
  • C-Reactive Protein
  • Sodium