Gliomas following low-dose irradiation to the head report of three cases

J Neurooncol. 1990 Feb;8(1):67-72. doi: 10.1007/BF00182089.


Three patients developed cerebral gliomas decades after exposure to low-dose x-ray irradiation in childhood for the treatment of tinea capitis. One of the patients had a glioblastoma multiforme concomitant with multiple intracranial meningiomas, a condition highly correlated with previous irradiation. The other tumors were malignant cerebellar astrocytoma and a diffuse cerebral astrocytoma. We review the evidence suggesting that low-dose irradiation is involved in the pathogenesis of gliomas.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Neoplasms / etiology*
  • Brain Neoplasms / pathology
  • Female
  • Glioma / etiology*
  • Glioma / pathology
  • Humans
  • Middle Aged
  • Neoplasms, Radiation-Induced / pathology*