Antagonistic effect of yangambin on platelet-activating factor (PAF)-induced cardiovascular collapse

E V Tibiriçá; K Mosquera; M Abreu; R Ribeiro; F A Carvalho; J M Barbosa-Filho; R S Cordeiro

doi:10.1016/S0944-7113(96)80048-1

Antagonistic effect of yangambin on platelet-activating factor (PAF)-induced cardiovascular collapse

Phytomedicine. 1996 Jan;2(3):235-42. doi: 10.1016/S0944-7113(96)80048-1.

Authors

E V Tibiriçá¹, K Mosquera, M Abreu, R Ribeiro, F A Carvalho, J M Barbosa-Filho, R S Cordeiro

Affiliation

¹ Departamento de Fisiologia e Farmacodinámica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.

PMID: 23194622
DOI: 10.1016/S0944-7113(96)80048-1

Abstract

The cardiovascular protective effects of yangambin, a novel and specific naturally-occurring platelet activating factor (PAF) receptor antagonist, were investigated in the pentobarbital anesthetized and artificially ventilated rat. Yangambin (3-30 mg kg(-1)) as well as the reference PAF antagonist WEB 2086 (0.1-1.0 mg kg(-1)) prevented the circulatory collapse elicited by the intravenous administration of PAF (0.5 μg kg(-1)), in a dose-dependent manner. Yangambin did not interfere with the hypotensive effect of several endogenous vasoactive mediators such as acetylcholine, bradykinin, histamine and serotonin. Moreover, when adminstered as a post-treatment the antagonist showed the ability to reverse the cardiovascular effects induced by PAF (1.0 μg kg(-1)). The protective effect of yangambin showed to have a duration of action of more than 2 hours. It is concluded that yangambin is a selective antagonist of the cardiovascular effects of PAF and therefore constitutes a potential therapeutic agent in different shock states where abnormal PAF release is supposed to play an important role.