Antispasmodic effects of hydroalcoholic extract of Marrubium vulgare on isolated tissues

V Schlemper; A Ribas; M Nicolau; V Cechinel Filho

doi:10.1016/S0944-7113(96)80038-9

Antispasmodic effects of hydroalcoholic extract of Marrubium vulgare on isolated tissues

Phytomedicine. 1996 Sep;3(2):211-6. doi: 10.1016/S0944-7113(96)80038-9.

Authors

V Schlemper¹, A Ribas, M Nicolau, V Cechinel Filho

Affiliation

¹ Núcleo de Investigações Químico-Farmaĉeuticas (NIQFAR)/Faculdade de Ciências Químico-Farmaĉeuticas (FAQFAR) - Universidade do Vale do Itajaí - UNIVALI, 88302-202, Itajaí, SC, Brazil.

PMID: 23194972
DOI: 10.1016/S0944-7113(96)80038-9

Abstract

Marrubium vulgare is a medicinal plant used in Brazil and in many countries in folk medicine against several diseases, including gastrointestinal disorders. In this study, we have evaluated the effects of hydroalcoholic extract of the roots and aerial parts of M. vulgare in several smooth muscle preparations in vitro. The results showed that this extract exert a significant antispasmodic activity which inhibits the action of some neurotransmitters, such as acetylcholine, bradykinin, prostaglandin E(2), histamine and oxytocin, with putative selectivity for cholinergic contractions. These findings support the popular use in folk medicine of this plant as an antispasmodic.