Whole body exposure to 2.4 GHz WIFI signals: effects on cognitive impairment in adult triple transgenic mouse models of Alzheimer's disease (3xTg-AD)

Behav Brain Res. 2013 Mar 1:240:197-201. doi: 10.1016/j.bbr.2012.11.021. Epub 2012 Nov 27.


The present investigation aimed at evaluating the effects of long-term exposure to WIFI type radiofrequency (RF) signals (2.40 GHz), two hours per day during one month at a Specific Absorption Rate (SAR) of 1.60 W/kg. The effects of RF exposure were studied on wildtype mice and triple transgenic mice (3xTg-AD) destined to develop Alzheimer's-like cognitive impairment. Mice were divided into four groups: two sham groups (WT, TG; n=7) and two exposed groups (WTS, TGS; n=7). The cognitive interference task used in this study was designed from an analogous human cognitive interference task including the Flex field activity system test, the two-compartment box test and the Barnes maze test. Our data demonstrate for the first time that RF improves cognitive behavior of 3xTg-AD mice. We conclude that RF exposure may represent an effective memory-enhancing approach in Alzheimer's disease.

MeSH terms

  • Alzheimer Disease* / genetics
  • Alzheimer Disease* / physiopathology
  • Amyloid beta-Protein Precursor / genetics
  • Animals
  • Behavior, Animal / radiation effects*
  • Cognition / radiation effects*
  • Disease Models, Animal
  • Electromagnetic Fields
  • Gene-Environment Interaction*
  • Humans
  • Mice
  • Mice, Transgenic
  • Presenilin-1 / genetics
  • Radio Waves*
  • tau Proteins / genetics


  • Amyloid beta-Protein Precursor
  • PSEN1 protein, human
  • Presenilin-1
  • tau Proteins