[No evidence of malicious effect of NSAID treatment on bone healing]

Ugeskr Laeger. 2012 Nov 26;174(48):3007-10.
[Article in Danish]


The use of NSAIDs for postoperative pain management following orthopaedic surgery or during conservative treatment of fractures is controversial. Experimental animal models suggest NSAIDs inhibit bone healing. In a review of the literature, there was no clinical evidence to support categorical discard of NSAID for postoperative pain relief in uncomplicated cases. However, NSAID should be considered a potentiel risk factor of impaired bone healing and avoided in patients with a high risk of pseudoarthrosis. Recommended daily doses should be respected and duration of treatment should be limited.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Bony Callus / drug effects*
  • Evidence-Based Medicine
  • Fracture Healing / drug effects*
  • Humans
  • Pain, Postoperative / drug therapy


  • Anti-Inflammatory Agents, Non-Steroidal