Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis

I Sakakibara; H Takahashi; S Terabayashi; M Yuzurihara; M Kubo; A Ishige; M Higuchi; Y Komatsu; M Okada; M Maruno; C Biqiang; H X Jiang

doi:10.1016/S0944-7113(98)80002-0

Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis

Phytomedicine. 1998 Apr;5(2):83-6. doi: 10.1016/S0944-7113(98)80002-0.

Authors

I Sakakibara¹, H Takahashi, S Terabayashi, M Yuzurihara, M Kubo, A Ishige, M Higuchi, Y Komatsu, M Okada, M Maruno, C Biqiang, H X Jiang

Affiliation

¹ Tsumura Central Research Laboratories, Amimachi, Inashikigun, Ibaraki, Japan.

PMID: 23195758
DOI: 10.1016/S0944-7113(98)80002-0

Abstract

Four tetracyclic oxindole alkaloids, rhynchophylline, isorhynchophylline, corynoxine and corynoxine B were isolated from the hooks of Uncaria macrophylla Wall. (Rubiaceae), that is a dominant plant widely distributed in Yunnan province. These compounds exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice.