The α2δ subunits of voltage-gated calcium channels

Biochim Biophys Acta. 2013 Jul;1828(7):1541-9. doi: 10.1016/j.bbamem.2012.11.019. Epub 2012 Nov 27.


Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together, except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which are collectively termed auxiliary or accessory subunits. This review will concentrate on the properties and role of the α2δ subunits of these channels. These proteins are largely extracellular, membrane-associated proteins which influence the trafficking, localization, and biophysical properties of the channels. This article is part of a Special Issue entitled: Calcium channels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / physiology*
  • Humans
  • Ion Channel Gating / physiology*
  • Protein Subunits


  • CACNA2D1 protein, human
  • CACNA2D1 protein, mouse
  • Calcium Channels
  • Protein Subunits
  • Calcium