Concise review: personalized human bone grafts for reconstructing head and face

Stem Cells Transl Med. 2012 Jan;1(1):64-9. doi: 10.5966/sctm.2011-0020. Epub 2011 Dec 7.


Regeneration of normal shape, architecture, and function of craniofacial tissues following congenital abnormality, trauma, or surgical treatment presents special problems to tissue engineering. Because of the great variations in properties of these tissues, currently available treatment options fall short of adequate care. We propose that the engineering of personalized bone graft customized to the patient and the specific clinical condition would revolutionize the way we currently treat craniofacial defects and discuss some of the current and emerging treatment modalities.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Regeneration
  • Bone Transplantation*
  • Cells, Cultured
  • Facial Bones / abnormalities
  • Facial Bones / injuries
  • Facial Bones / surgery*
  • Humans
  • Plastic Surgery Procedures*
  • Skull / abnormalities
  • Skull / injuries
  • Skull / surgery*
  • Stem Cell Transplantation*
  • Tissue Engineering*
  • Tissue Scaffolds