Divide Et Impera--cellular auxin compartmentalization

Curr Opin Plant Biol. 2013 Feb;16(1):78-84. doi: 10.1016/j.pbi.2012.10.005. Epub 2012 Nov 27.


The phytohormone auxin is an essential regulator for plant growth and development. Decades of intensive research revealed the mutual importance of auxin metabolism and intercellular cell-to-cell transport for the regulation of spatiotemporal auxin distribution. Just recently, intracellular putative auxin carriers, such as the PIN-FORMED (PIN)5/PIN8 and the PIN-LIKES (PILS)2/PILS5 were discovered at the endoplasmic reticulum (ER) and seem to limit nuclear auxin signaling via an auxin sequestration mechanism. Moreover, these auxin carriers at the ER might provide a link between auxin compartmentalization and auxin conjugation-based metabolism. Here we review the recent findings on auxin compartmentalization at the ER and discuss its potential contribution to cellular auxin homeostasis and its importance for plant development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Transport
  • Cell Compartmentation
  • Endoplasmic Reticulum / metabolism
  • Homeostasis
  • Indoleacetic Acids / metabolism*
  • Plant Development*
  • Plant Growth Regulators / metabolism*
  • Plant Proteins / metabolism*
  • Plants / metabolism
  • Signal Transduction


  • Indoleacetic Acids
  • Plant Growth Regulators
  • Plant Proteins