Titivated for destruction: the methyl degron

Mol Cell. 2012 Nov 30;48(4):487-8. doi: 10.1016/j.molcel.2012.11.007.


In this issue, Lee et al. (2012) demonstrate that the degradation of RORα is regulated by the EZH2-DCAF1/DDB1/CUL4 proteasome axis, thus identifying protein methylation as a posttranslational modification that can orchestrate protein destruction through a motif termed the "methyl degron."

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