Taking a cellular road-trip: mRNA transport and anchoring

Curr Opin Cell Biol. 2013 Feb;25(1):99-106. doi: 10.1016/j.ceb.2012.08.015. Epub 2012 Nov 30.

Abstract

mRNA localization is a crucial mechanism for post-transcriptional control of gene expression used in numerous cellular contexts to generate asymmetric enrichment of an encoded protein. This process has emerged as a fundamental regulatory mechanism that operates in a wide range of organisms to control an array of cellular processes. Recently, significant advances have been made in our understanding of the mechanisms that regulate several steps in the mRNA localization pathway. Here we discuss the progress made in understanding localization element recognition, paying particular attention to the role of RNA structure. We also consider the function of mRNP granules in mRNA transport, as well as new results pointing to roles for the endocytic pathway in mRNA localization.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Endocytosis
  • Eukaryotic Cells / metabolism
  • Humans
  • Nucleic Acid Conformation
  • RNA Transport*
  • RNA, Messenger / chemistry
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • Ribonucleoproteins / metabolism

Substances

  • RNA, Messenger
  • Ribonucleoproteins
  • messenger ribonucleoprotein