Losing your inhibition: linking cortical GABAergic interneurons to schizophrenia

Neurobiol Dis. 2013 May:53:36-48. doi: 10.1016/j.nbd.2012.11.013. Epub 2012 Nov 29.


GABAergic interneurons of the cerebral cortex (cINs) play crucial roles in many aspects of cortical function. The diverse types of cINs are classified into subgroups according to their morphology, intrinsic physiology, neurochemical markers and synaptic targeting. Recent advances in mouse genetics, imaging and electrophysiology techniques have greatly advanced our efforts to understand the role of normal cIN function and its dysfunction in neuropsychiatric disorders. In schizophrenia (SCZ), a wealth of data suggests that cIN function is perturbed, and that interneuron dysfunction may underlie key symptoms of the disease. In this review, we discuss the link between cINs and SCZ, focusing on the evidence for GABAergic signaling deficits from both SCZ patients and mouse models.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cerebral Cortex / pathology*
  • Cerebral Cortex / physiology
  • GABAergic Neurons / pathology*
  • GABAergic Neurons / physiology
  • Humans
  • Interneurons / pathology*
  • Interneurons / physiology
  • Neural Inhibition / physiology*
  • Schizophrenia / pathology*
  • Schizophrenia / physiopathology
  • gamma-Aminobutyric Acid / physiology


  • gamma-Aminobutyric Acid