Disability caused by multiple sclerosis is associated with the number of extra cranial venous stenoses: possible improvement by venous angioplasty. Results of a prospective study

Phlebology. 2013 Oct;28(7):353-60. doi: 10.1258/phleb.2012.012065. Epub 2013 May 6.


Objective: Chronic cerebrospinal venous insufficiency (CCSVI) was recently described in patients with multiple sclerosis (MS). The hypothesis of the vascular aetiology provides a new approach in the investigation and treatment of MS.

Methods: Our open-label study included 94 MS patients who fulfilled ultrasound sonographic criteria required for CCSVI. The internal jugular and/or azygous veins by a catheter venography were dilated.

Results: In 34.8% of the patients unilateral, in 65.2% bilateral venous abnormalities and in 2.1% no luminal obstructions were demonstrated. The patient group with the higher disability score had a significantly higher number of venous lesions (P < 0.005). Significant improvement of clinical disability in relapsing-remitting patients was (P < 0.001) achieved. In our study no stents were used. Re-stenosis occurred in 21.7% of the patients.

Conclusion: The number of venous narrowings is higher in more disabled patients. A significant improvement in clinical disability in the relapsing-remitting group was observed.

Keywords: angioplasty; interventional radiology; multiple sclerosis; venous pathology.

Publication types

  • Clinical Trial

MeSH terms

  • Angioplasty, Balloon*
  • Constriction, Pathologic
  • Female
  • Humans
  • Male
  • Multiple Sclerosis* / complications
  • Multiple Sclerosis* / diagnostic imaging
  • Multiple Sclerosis* / therapy
  • Prospective Studies
  • Ultrasonography
  • Venous Insufficiency* / diagnostic imaging
  • Venous Insufficiency* / etiology
  • Venous Insufficiency* / therapy