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Clinical Trial
. 2013 Oct;28(7):353-60.
doi: 10.1258/phleb.2012.012065. Epub 2013 May 6.

Disability Caused by Multiple Sclerosis Is Associated With the Number of Extra Cranial Venous Stenoses: Possible Improvement by Venous Angioplasty. Results of a Prospective Study

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Clinical Trial

Disability Caused by Multiple Sclerosis Is Associated With the Number of Extra Cranial Venous Stenoses: Possible Improvement by Venous Angioplasty. Results of a Prospective Study

M Denislic et al. Phlebology. .

Abstract

Objective: Chronic cerebrospinal venous insufficiency (CCSVI) was recently described in patients with multiple sclerosis (MS). The hypothesis of the vascular aetiology provides a new approach in the investigation and treatment of MS.

Methods: Our open-label study included 94 MS patients who fulfilled ultrasound sonographic criteria required for CCSVI. The internal jugular and/or azygous veins by a catheter venography were dilated.

Results: In 34.8% of the patients unilateral, in 65.2% bilateral venous abnormalities and in 2.1% no luminal obstructions were demonstrated. The patient group with the higher disability score had a significantly higher number of venous lesions (P < 0.005). Significant improvement of clinical disability in relapsing-remitting patients was (P < 0.001) achieved. In our study no stents were used. Re-stenosis occurred in 21.7% of the patients.

Conclusion: The number of venous narrowings is higher in more disabled patients. A significant improvement in clinical disability in the relapsing-remitting group was observed.

Keywords: angioplasty; interventional radiology; multiple sclerosis; venous pathology.

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