Periurethral injection of polyacrylamide hydrogel for the treatment of stress urinary incontinence: the impact on female sexual function

J Sex Med. 2012 Dec;9(12):3255-63. doi: 10.1111/j.1743-6109.2012.02955.x.


Introduction: Urinary incontinence can negatively affect sexual function.

Aim: To investigate sexual function in female patients treated for urodynamic stress incontinence (USI) by periurethral injections.

Methods: This double-center prospective study included 29 female patients who were treated for USI by periurethral injections of polyacrylamide hydrogel (Bulkamid(®); Ethicon Women's Health and Urology, Contura, Denmark).

Main outcome measures: Patients answered the International Consultation on Incontinence Questionnaire short form, the Incontinence Impact Questionnaire, and the Patient Global Improvement Impression. The Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire-12 (PISQ-12) was used to evaluate sexual function at baseline and at 1-year follow-up. Patients were also asked to rate their sexual activity by using a 10-mm visual analog scale at baseline and at 12-month follow-up. Subjective and objective success was examined.

Results: All patients were discharged on the same day of treatment and there was no intraoperative complication. At 1-year follow-up, the subjective success rate was 89.7% and the objective success rate was 79.3%. At 1 year from the first treatment, all the 23 sexually active patients continued to have regular sexual life. Six women reestablished sexual activity after the treatment. The total PISQ-12 scores showed a significant improvement in quality of sexual life of patients who were sexually active before surgery.

Conclusions: Periurethral injections of polyacrylamide hydrogel to treat USI are clinically effective and safe. These surgical procedures cause significant improvements in sexual function and sexual satisfaction of patients.

Publication types

  • Multicenter Study

MeSH terms

  • Acrylic Resins / therapeutic use*
  • Adult
  • Aged
  • Female
  • Follow-Up Studies
  • Gels
  • Humans
  • Injections
  • Middle Aged
  • Prospective Studies
  • Quality of Life*
  • Sexual Behavior*
  • Surveys and Questionnaires
  • Urethra
  • Urinary Incontinence, Stress / therapy*


  • Acrylic Resins
  • Gels
  • polyacrylamide gels