Molecular control of axon growth: insights from comparative gene profiling and high-throughput screening

Int Rev Neurobiol. 2012;105:39-70. doi: 10.1016/B978-0-12-398309-1.00004-4.

Abstract

Axon regeneration in the mammalian adult central nervous system (CNS) is limited by an intrinsically low capacity for axon growth in many CNS neurons. In contrast, embryonic, peripheral, and many nonmammalian neurons are capable of successful regeneration. Numerous studies have compared mammalian CNS neurons to their counterparts in regenerating systems in an effort to identify candidate genes that control regenerative ability. This review summarizes work using this comparative strategy and examines our current understanding of gene function in axon growth, highlighting the emergence of genome-wide expression profiling and high-throughput screening strategies to identify novel regulators of axon growth.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Gene Expression Profiling / methods*
  • Gene Expression Profiling / trends
  • High-Throughput Screening Assays / methods*
  • High-Throughput Screening Assays / trends
  • Humans
  • Nerve Regeneration / physiology
  • Peripheral Nervous System Diseases / diagnosis
  • Peripheral Nervous System Diseases / genetics