Surgical management of malignant pleural mesothelioma

Thorac Surg Clin. 2013 Feb;23(1):73-87, vi. doi: 10.1016/j.thorsurg.2012.10.002.


The uniquely diffuse nature of malignant pleural mesothelioma (MPM) makes it difficult to diagnose, stage, and treat. In addition, it is a relatively uncommon disease, making adequate prospective trials difficult to perform and leading to several controversies regarding the best management of MPM. Perhaps the greatest area of dispute is whether extrapleural pneumonectomy or pleurectomy/decortication is the most appropriate curative operation for patients who are physiologically candidates for both. Although median survival remains poor, important strides have been made in the treatment of MPM, mainly in the form of multimodality therapeutic regimens.

Publication types

  • Review

MeSH terms

  • Combined Modality Therapy / methods
  • Humans
  • Medical Illustration
  • Mesothelioma / diagnosis
  • Mesothelioma / surgery*
  • Mesothelioma / therapy
  • Occupational Diseases / diagnosis
  • Occupational Diseases / surgery
  • Occupational Diseases / therapy
  • Pleura / surgery
  • Pleural Neoplasms / diagnosis
  • Pleural Neoplasms / surgery*
  • Pleural Neoplasms / therapy
  • Pneumonectomy
  • Prospective Studies
  • Thoracic Surgical Procedures
  • Treatment Outcome