A multicenter study on the prevalence of eosinophilic esophagitis and PPI-responsive esophageal eosinophilic infiltration

Intern Med. 2012;51(23):3235-9. doi: 10.2169/internalmedicine.51.8670. Epub 2012 Dec 1.


Objective: Eosinophilic esophagitis (EoE) is diagnosed by the presence of dysphagia and intraepithelial eosinophilic infiltration of ≥15 per high-power field (HPF). EoE should be distinguished from proton pump inhibitor-responsive esophageal eosinophilic infiltration (PPI-R EEI) in patients that are responsive to PPI treatment. The aim of this study was to determine the prevalence of EoE and PPI-R EEI in Japanese patients in a multicenter study.

Methods: Ten hospitals participated in this study. Esophageal biopsy was performed when the patients had typical EoE symptoms or when endoscopic findings revealed a typical EoE appearance. EEI was defined as the intraepithelial eosinophilic infiltration of ≥15 per HPF. Patients with EEI received rabeprazole for 8 weeks to distinguish EoE from PPI-R EEI.

Results: A total of 13,634 subjects that underwent upper gastrointestinal endoscopy because of further examination or as a routine checkup were enrolled. Seventy-one (0.5%) patients suspected with EoE were examined by biopsy. A histological examination of 7 (9.9%) cases revealed EEI. Two of these 7 patients showed no symptoms and the other 5 were treated with PPI. Two (0.01%) patients were diagnosed with EoE and 3 (0.02%) with PPI-R EEI.

Conclusion: EoE and PPI-R EEI were rare in Japanese patients that underwent upper gastrointestinal endoscopy.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Eosinophilia / pathology
  • Eosinophilic Esophagitis / drug therapy
  • Eosinophilic Esophagitis / epidemiology*
  • Eosinophilic Esophagitis / pathology
  • Esophagus / pathology
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Prevalence
  • Proton Pump Inhibitors / therapeutic use


  • Proton Pump Inhibitors