A longitudinal case-control study of caries development from birth to 36 months

Caries Res. 2013;47(2):117-27. doi: 10.1159/000345073. Epub 2012 Nov 27.

Abstract

Background/aims: The aim of this longitudinal case-control study was to investigate variables associated with caries development from birth to 36 months.

Methods: Children (n = 1,017) who were followed up every 6 months from birth to 36 months were grouped into those that developed caries by age 30 and 36 months, respectively, and compared with children without caries.

Results: By 30 months (n = 608) there were 24 children (4%) who had caries and an additional 23 developed first caries at 36 months (n = 552), giving a total prevalence of 47 children with caries (9%) at 36 months. Children who showed caries by 30 months were more likely to be mutans streptococci (MS) colonised by 18 months (p = 0.001) compared to those who developed caries at 36 months, and showed the following variables: MS counts of >10(5) CFU/ml at 12 months (p = 0.005), missing enamel (p = 0.001), sugar in pacifier at 18 months (p = 0.02), child sleeping next to mother at 6, 18 and 24 months (p = 0.001 to p = 0.02), and exposure to household cigarette smoke at 24 months (p = 0.02). Caries at 36 months was associated with pregnancy problems (p = 0.024), mother having dental cavitations (p = 0.001) and MS presence at 36 months (adjusted odds ratio, AOR = 0.1, p = 0.01 for counts <10(5) CFU/ml). Caries at both 30 and 36 months was associated with MS presence at 18 months (AOR = 6.3, p = 0.005 and AOR = 4.9, p = 0.01).

Conclusions: Children who developed caries by 30 months are colonised by MS at younger ages and with higher MS counts compared with children who develop caries at 36 months.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Anti-Infective Agents, Local / therapeutic use
  • Bacterial Load
  • Cariostatic Agents / therapeutic use
  • Case-Control Studies
  • Caseins / therapeutic use
  • Child, Preschool
  • Chlorhexidine / therapeutic use
  • Cohort Studies
  • Dental Caries / etiology*
  • Dental Caries / microbiology
  • Dental Enamel / pathology
  • Dietary Sucrose / administration & dosage
  • Environmental Exposure
  • Female
  • Fluorides / therapeutic use
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Lactobacillus / isolation & purification
  • Longitudinal Studies
  • Mother-Child Relations
  • Pacifiers
  • Pregnancy
  • Pregnancy Complications / microbiology
  • Sleep / physiology
  • Streptococcus mutans / isolation & purification
  • Tobacco Smoke Pollution / adverse effects
  • Toothbrushing / methods

Substances

  • Anti-Infective Agents, Local
  • Cariostatic Agents
  • Caseins
  • Dietary Sucrose
  • Tobacco Smoke Pollution
  • casein phosphopeptide-amorphous calcium phosphate nanocomplex
  • Fluorides
  • Chlorhexidine