Weight-loss diet alone or combined with progressive resistance training induces changes in association between the cardiometabolic risk profile and abdominal fat depots

Ann Nutr Metab. 2012;61(4):296-304. doi: 10.1159/000342467. Epub 2012 Dec 3.


Background/aims: A weight-loss diet alone or combined with a progressive resistance training program induced different adaptations on cardiometabolic risk, i.e. regional changes in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volume distribution patterns. We hypothesized that a heterogeneous adipose tissue metabolism may exist between visceral fat at different discal levels.

Methods: Thirty-four obese women, aged 40-60 years, were randomized to three groups: a control group (n = 9), a diet group (WL; n = 12) with a caloric restriction of 500 kcal/day during 16 weeks, or a diet-plus-resistance-training group (WL+RT; n = 13) with the same caloric restriction and a 16-week resistance training of 2 sessions per week.

Results: The association pattern between abdominal fat depots and glucose metabolism variables showed a change from the L4-L5 region (preintervention) to VAT L2-L3 and SAT L2-L3 in the WL and WL+RT groups, respectively. It is noteworthy that accumulation of fat in the midthigh was not characterized by a more favorable lipid profile or glucose metabolism.

Conclusion: Our results reinforce the importance of considering L2-L3 images to predict insulin resistance after a weight-loss diet, alone or combined with resistance training.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Body Mass Index
  • Caloric Restriction*
  • Cardiovascular Diseases / diet therapy*
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Diet, Reducing*
  • Energy Intake / physiology
  • Energy Metabolism / physiology
  • Female
  • Humans
  • Insulin / blood
  • Insulin Resistance
  • Intra-Abdominal Fat / metabolism*
  • Magnetic Resonance Imaging
  • Middle Aged
  • Obesity / diet therapy
  • Resistance Training / methods*
  • Risk Factors
  • Subcutaneous Fat / metabolism


  • Biomarkers
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Insulin