Consumption of dairy products and death from cardiovascular disease in the Japanese general population: the NIPPON DATA80

J Epidemiol. 2013;23(1):47-54. doi: 10.2188/jea.je20120054. Epub 2012 Dec 1.


Background: Recent Western studies show an inverse association between milk and dairy product intake and cardiovascular disease (CVD). We studied the association between consumption of milk and dairy products and CVD death in Japan.

Methods: Men and women aged 30 years or older were followed for 24 years. All had participated in a national nutrition survey in 300 health districts throughout Japan in 1980. The Cox proportional hazards model was used to assess mortality risk according to tertiles of milk and dairy product intake, with the high consumption group as reference. Hazard ratios (HRs) per 100-g/day increase in consumption were also estimated.

Results: During the 24-year follow-up period, there were 893 CVD deaths, 174 deaths from coronary heart disease (CHD), and 417 stroke deaths among 9243 participants. For women, the HRs for death from CVD, CHD, and stroke in the low consumption group were 1.27 (95% CI: 0.99-1.58; P for trend = 0.045), 1.67 (0.99-2.80; P = 0.02), and 1.34 (0.94-1.90; P = 0.08), respectively, after adjustment for age, body mass index, smoking status, alcohol drinking habits, history of diabetes, use of antihypertensives, work category, and total energy intake. With each 100-g/day increase in consumption of milk and dairy products, HRs tended to decrease for deaths from CVD (HR, 0.86; 95% CI, 0.74-0.99), CHD (0.73; 0.52-1.03), and stroke (0.81; 0.65-1.01) in women. No significant association was observed in men.

Conclusions: Consumption of milk and dairy products was inversely associated with CVD death among women in Japan.

【背景】: 近年、牛乳・乳製品の摂取と循環器疾患との負の関連が西洋諸国の研究で報告されている。本研究では、日本における牛乳・乳製品の摂取と循環器疾患死亡との関連について検討した。

【方法】: 1980年に日本全体の300地区で実施した国民栄養調査の対象者のうち30歳以上の男女を24年間追跡した。牛乳・乳製品摂取量の3分位間の死亡リスクをコックスの比例ハザードモデルにより高摂取群を基準として算出した。また、摂取量1日100g増加あたりのハザード比も算出した。

【結果】: 対象者9,243人の24年間の追跡期間における循環器疾患死亡は893人で、そのうち心疾患死亡が174人、脳血管疾患死亡が417人であった。女性において、低摂取群の循環器疾患死亡、心疾患死亡、脳血管疾患死亡のハザード比は年齢、BMI、喫煙習慣、飲酒習慣、糖尿病歴、降圧剤服薬、職業区分および総エネルギー摂取量を調整した場合それぞれ1.27(95%信頼区間:0.99-1.58;トレンドp=0.045)、1.67(0.99-2.80;p=0.02)、1.34(0.94-1.90;p=0.08)であった。牛乳・乳製品1日100g摂取増加毎のハザード比は、女性において循環器疾患死亡0.86(0.74-0.99)、心疾患死亡 0.73(0.52-1.03)、脳血管疾患死亡 0.81(0.65-1.01)で低下傾向にあった。男性では有意な関連は見られなかった。

【結論】: 牛乳・乳製品の摂取は日本において女性で循環器疾患死亡と負の関連があった。

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Cardiovascular Diseases / mortality*
  • Dairy Products*
  • Diet / statistics & numerical data*
  • Female
  • Follow-Up Studies
  • Health Surveys
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Milk
  • Proportional Hazards Models
  • Risk Assessment
  • Sex Distribution