Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

Chem Commun (Camb). 2013 Jan 21;49(6):564-6. doi: 10.1039/c2cc37460a. Epub 2012 Dec 4.

Abstract

Formyl Peptide Receptors (FPRs) are vital in the host inflammatory response, playing an important regulatory role in multiple diseases. A Gd(III) DOTA conjugate of cFLFLFK has been synthesised which targets and visualises FPR1 upon leukocytes in the inflammatory response via magnetic resonance imaging for the first time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / diagnostic imaging
  • Contrast Media / chemistry*
  • Coordination Complexes / chemistry
  • Gadolinium / chemistry*
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Inflammation / metabolism
  • Inflammation / pathology
  • Ions / chemistry
  • Leukocytes / metabolism
  • Magnetic Resonance Imaging
  • Mice
  • Oligopeptides / chemistry*
  • Oligopeptides / metabolism
  • Protein Binding
  • Radiography
  • Receptors, Formyl Peptide / chemistry
  • Receptors, Formyl Peptide / metabolism*

Substances

  • Contrast Media
  • Coordination Complexes
  • Heterocyclic Compounds, 1-Ring
  • Ions
  • Oligopeptides
  • Receptors, Formyl Peptide
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • Gadolinium