Poly(2-oxazoline)-derived contact biocides: contributions to the understanding of antimicrobial activity

Macromol Biosci. 2013 Jan;13(1):116-25. doi: 10.1002/mabi.201200240. Epub 2012 Dec 3.


A set of poly(2-oxazoline)-derived (co-)polymers was prepared by microwave-assisted polymerizations and acid-mediated hydrolysis and tested for antimicrobial activity in 50 × 50 × 2 mm PP compound plates containing 5 wt% of the polymers. Antimicrobial activity against gram-negative E. coli and P. aeruginosa as well as C. albicans depended only on the degree of hydrolysis, while antimicrobial activity against gram-positive S. aureus was only observed for hydrolyzed poly(2-nonyl-2-oxazoline)s. The surface energies of the compound plates compared to pure PP were hardly altered, and the compounds can be considered as alternatives for PP. The presence of the biocide additives at the surface of the PP compound plates could be shown by combined ATR-IR, zeta potential, and SEM-EDX measurements. Antimicrobial activity was maintained during double incubation as well as for lowered amounts of the biocide additive of 1% in PP compound plates.

MeSH terms

  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / chemistry
  • Candida albicans / drug effects
  • Disinfectants / chemical synthesis*
  • Disinfectants / chemistry
  • Escherichia coli / drug effects
  • Hydrolysis
  • Microbial Sensitivity Tests
  • Oxazoles / chemistry*
  • Polymerization
  • Polymers / chemistry
  • Pseudomonas aeruginosa / drug effects
  • Staphylococcus aureus / drug effects


  • Anti-Infective Agents
  • Disinfectants
  • Oxazoles
  • Polymers
  • poly(2-oxazoline)