Serum glycated albumin is inversely influenced by fat mass and visceral adipose tissue in Chinese with normal glucose tolerance

PLoS One. 2012;7(11):e51098. doi: 10.1371/journal.pone.0051098. Epub 2012 Nov 29.

Abstract

Background: Recent studies have revealed that body mass index (BMI) inversely influenced serum glycated albumin (GA), which may cause an underestimation of GA-monitored short-term hyperglycemic control.

Objective: This study was to investigate the association between anthropometric variables (BMI and waist circumference (W)) and accurate adiposity variables (percentage of body fat (%fat), fat mass, free fat mass (FFM), subcutaneous fat area (SFA), and visceral fat area (VFA)) with serum GA.

Design: A total of 2563 subjects (1037 men, 593 premenopausal women, and 933 postmenopausal women) with normal glucose tolerance underwent bioelectrical impedance body fat content measurement and magnetic resonance imaging. Serum GA and absolute value of GA (aGA) were measured by enzymatic assay.

Results: Compared to the BMI <25.0 kg/m(2) group, the BMI ≥25.0 kg/m(2) group had significantly higher fasting plasma glucose, glycated hemoglobin A1c, and body fat parameters including W, %fat, fat mass, FFM, SFA, and VFA, but significantly lower aGA, and GA in all the three sex- and menopause-stratified groups (all P<0.05). GA decreased with the increment of fat mass for all three groups (all P for trend <0.001). In the same BMI category, men and postmenopausal women with elevated %fat (men, ≥25%; women, ≥35%) still had significantly lower GA than those with normal %fat (men, <25%; women, <35%) (all P<0.05). Multiple stepwise regression showed that %fat, fat mass, and VFA were independently associated with GA.

Conclusions: Serum GA was inversely influenced by fat mass and visceral adipose tissue in Chinese with normal glucose tolerance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / metabolism
  • Anthropometry
  • Asian People
  • Blood Glucose / metabolism
  • Body Composition / physiology
  • Body Mass Index
  • Female
  • Glycated Serum Albumin
  • Glycation End Products, Advanced
  • Humans
  • Intra-Abdominal Fat / metabolism*
  • Male
  • Middle Aged
  • Obesity / metabolism
  • Serum Albumin / metabolism*
  • Waist Circumference

Substances

  • Blood Glucose
  • Glycation End Products, Advanced
  • Serum Albumin
  • Glycated Serum Albumin

Grants and funding

This work was funded by 973 Program of China (2012CB524906), Project of National Natural Science Foundation of China (81170788 and 81100563), National Key Technology R&D Program of China (2009BAI80B01), the Shanghai Municipal Health Bureau Youth Projects (2010Y032), and Shanghai United Developing Technology Projects of Municipal Hospitals (SHDC12010115). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.