Patient-specific whole-body attenuation correction maps from a CT system for conjugate-view-based activity quantification: method development and evaluation

Cancer Biother Radiopharm. 2012 Dec;27(10):652-64. doi: 10.1089/cbr.2011.1082.


For activity quantification based on planar scintillation camera measurements, photon attenuation is an important factor that needs to be corrected for in a patient- and organ-specific manner. One possibility for obtaining attenuation correction maps is to use X-ray CT scout images. Since the intensity of scout images is in relative numbers, their image values need to be multiplied by a factor to become quantitative and thus useful for attenuation correction. The calibration factor can for our current imaging system be obtained from a scanner system file, but is generally not available. For this purpose, a method based on the patient weight has been developed. Results based on 79 patient scout images show that the calibration factor thus determined correlates well with values that, in this case, are independently specified by the system. The accuracy of attenuation correction factors (ACFs) derived from the scout-based attenuation correction maps is evaluated by comparison to ACFs derived from three-dimensional CT studies. For photon energies of 208, 245, and 364 keV, scout-based ACFs are on average 1.2% and 0.5% from the CT-derived values, using the system-based and the weight-based values of the scout-image calibration factor, respectively. The imprecision is somewhat higher for the weight-based method, due to variability in the delineation of the patient contour used as a part of this method. In conclusion, X-ray scouts are found useful for attenuation correction with a satisfactory accuracy obtained, both using the new, weight-based method, and using the previous, system-based method, for determining the required calibration factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Humans
  • Indium Radioisotopes
  • Iodine Radioisotopes
  • Lymphoma, B-Cell / diagnostic imaging
  • Lymphoma, B-Cell / pathology
  • Male
  • Neuroendocrine Tumors / diagnostic imaging
  • Neuroendocrine Tumors / pathology
  • Photons
  • Precision Medicine / methods
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Radiotherapy Planning, Computer-Assisted / methods*
  • Scintillation Counting / methods
  • Tomography, X-Ray Computed / methods*
  • Whole Body Imaging / methods*
  • Whole-Body Counting
  • Yttrium Radioisotopes


  • Indium Radioisotopes
  • Iodine Radioisotopes
  • Radiopharmaceuticals
  • Yttrium Radioisotopes