Association between CCL2 haplotypes and knee osteoarthritis

Int J Immunogenet. 2013 Aug;40(4):280-3. doi: 10.1111/iji.12015. Epub 2012 Dec 4.

Abstract

We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in the control group (f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA.

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • Biomarkers
  • Chemokine CCL2 / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genotype
  • Haplotypes / genetics
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis, Knee / epidemiology
  • Osteoarthritis, Knee / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Sex Factors
  • Young Adult

Substances

  • Biomarkers
  • CCL2 protein, human
  • Chemokine CCL2